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![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-1.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-2.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-3.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-4.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-5.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0578-6.jpg)
![LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/product/cell-line-new.jpg)
產(chǎn)品概述
| 名稱 | LN229 [LN-229; LNT-229] (人膠質(zhì)母細(xì)胞瘤細(xì)胞) (STR鑒定正確) |
| 別稱 | LN 229; LN229; LNT-229 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:5 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | The LN-229 cell line was Established in 1979 from cells taken from a patient with right frontal parieto-occipital glioblastoma [PubMed. 10416987]. |
| 年齡（性別） | 女性；60歲 |
| 組織來源 | 大腦/右額葉頂枕葉皮質(zhì) |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 膠質(zhì)母細(xì)胞瘤細(xì)胞 |
| 生物安全等級 | BSL-1 |
| 倍增時(shí)間 | ~31 hours |
| 致瘤性 | Yes, forms tumors in nude mice. |
| 保藏機(jī)構(gòu) | ATCC; CRL-2611 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 12 D2S1338 19,20 D3S1358 16,17 D5S818 11,12 D7S820 8,11 D8S1179 13,14 D13S317 10,11 D16S539 12 D18S51 13,15 D19S433 12,17.2 D21S11 29,30 FGA 23 PentaD 10,11 PentaE 7,16 TH01 9.3 TPOX 8 vWA 16,19 D6S1043 11 D12S391 20,22 D2S441 10,11 -
STR鑒定圖
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參考文獻(xiàn)
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Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia(2024/03/30)
作者：Han Xie, Yanyi Jiang, Yufei Xiang
期刊：NEURO-ONCOLOGY
影響因子 ：15.900
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SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma(2022/12/24)
作者：Liying Han, Jinpeng Zhou, Leiyang Li
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-05526-w
影響因子 ：9.000
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Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy(2021/08/06)
作者：Zhenzhen Liu, Xiaoning Liu, Ruicheng Fan
期刊：Acta Pharmacologica Sinica
DOI：10.1038/s41401-021-00724-2
影響因子 ：8.200
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Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression(2023/10/12)
作者：Jinfeng Zhu, Qitong Chen, Liyun Zeng
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1236806
影響因子 ：7.300
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Hsa_circ_0021205 enhances lipolysis via regulating miR-195-5p/HSL axis and drives malignant progression of glioblastoma(2024/02/10)
作者：Suwen Li, Jiaqi Yuan, Zhe Cheng
期刊：Cell Death Discovery
DOI：10.1038/s41420-024-01841-7
影響因子 ：7.000
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Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes(2024/04/02)
作者：Kan Wang, Yifei Xiao, Ruipeng Zheng
期刊：Cancer Cell International
DOI：10.1186/s12935-024-03316-2
影響因子 ：5.800
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Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients(2021/05/29)
作者：Zhendong Liu, Wang Zhang, Xingbo Cheng
期刊：Molecular Medicine
DOI：10.1186/s10020-021-00316-0
影響因子 ：5.700
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Nifuroxazide inhibits the growth of glioblastoma and promotes the infiltration of CD8 T cells to enhance antitumour immunity(2023/03/14)
作者：Xinzhuang Wang, Junyi Ye, Ming Gao
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.109987
影響因子 ：5.600
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A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response(2023/10/18)
作者：Wei-Wei Duan, Li-Ting Yang, Jian Liu
期刊：CNS Neuroscience & Therapeutics
影響因子 ：5.500
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Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma(2024/04/11)
作者：Zhen Liu, Liangwang Yang, Wenqi Wu
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2024.1375030
影響因子 ：5.500
引用產(chǎn)品：CL-0578
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RNA-binding protein DHX9 promotes glioma growth and tumor-associated macrophages infiltration via TCF12(2022/11/15)
作者：Liang Liu, Xuelan Zhou, Shan Cheng, Yuyuan Ge, Baomin Chen, Jia Shi, Haoran Li, Suwen Li, Yongdong Li, Jiaqi Yuan, Anyi Wu, Xinglei Liu, Shilu Huang, Zhipeng Xu, Jun Dong
期刊：CNS Neuroscience & Therapeutics
影響因子 ：5.500
引用產(chǎn)品：CL-0012 CL-0233 CL-0237 CL-0458 CL-0578 CL-0583 CP-H122
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A novel immunogenic cell death-related gene risk signature can identify biomarkers of gliomas and predict the immunotherapeutic response(2024/01/15)
作者：Xuewu Tang, Kan Wang, Jinchao Yang
期刊：American Journal of Cancer Research
DOI：PMID:38323285
影響因子 ：5.300
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A novel necroptosis-related gene signature for predict prognosis of glioma based on single-cell and bulk RNA sequencing.(2022/08/30)
作者：Kai Guo, Xinxin Duan, Jiahui Zhao
期刊：Frontiers in Molecular Biosciences
影響因子 ：5.000
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Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis(2021/8/31)
作者：Xian Bao, Yibo Peng, Jun Shen
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DOI：10.1080/21655979.2021.1976712
影響因子 ：4.900
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Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p(2021/10/28)
作者：Yi Sun, Yulong Shen, Xing Li
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DOI：10.1080/21655979.2021.1995573
影響因子 ：4.900
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The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells(2021/11/18)
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Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells(2023/06/03)
作者：Yan Wang, Jingwei Peng, Chenchen Song
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DOI：10.1016/j.heliyon.2023.e17000
影響因子 ：4.000
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Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma(2024/04/16)
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CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis(2021/10/09)
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DOI：10.1186/s12885-021-08803-7
影響因子 ：3.800
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Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281(2022/01/04)
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DOI：10.1007/s12640-021-00464-5
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Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway(2024/03/28)
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Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis(2022/11/03)
作者：Xiao, Gaopeng, Yu, Liuqiong, Tan, Wenmin, Yang, Hao, Li, Wensen, Xia, Rongzhou, Li, Yujin
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DOI：10.1007/s11011-022-01099-x
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CircTTBK2 Contributes to the Progression of Glioma Through Regulating miR-145-5p/CPEB4 Axis(2020/9/8)
作者：Yan Liu, Ruilong Li, Xuan Wang
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VSIG4 Silencing Inhibits Glioblastoma Growth by Regulating the JAK2/STAT3 Pathway(2023/06/02)
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HNF4G accelerates glioma progression by facilitating NRP1 transcription(2023/02/01)
作者：Hongmin Che, Qi Zheng, Zijun Liao
期刊：Oncology Letters
影響因子 ：2.900
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